Program - February 11
The time indicated in the schedule is intended as Central European Time
9:00 Welcome by Manuela Baccarini
SESSION 1 : AUTOPHAGY AND PROTEOSTASIS
9:15 Ivan Dikic "ER-phagy and neuropathologies"
10:00 Thorsten Hoppe "Stressed Out: Posttranscriptional Proteostasis Regulation"
10:45 Break
11:00 Brenda Schulman "How Cullin-RING ligases ubiquitylate their substrates"
11:45 Peter Tompa "Tripartite degron model: the role of structural disorder in coordinated protein degradation in the cell"
12:30 Break
SESSION 2: SIGNALLING IN HEALTH AND DISEASE
13:30 Dario Alessi "Interplay between LRRK2 kinase and Rab GTPases in Parkinson's disease"
14:15 Chiara Ambrogio "Insights into KRAS biology to identify novel therapeutic strategies for cancer"
15:00 Michael Eck "Pharmacologic insights from cryo-EM structures of autoinhibited and active-state structures
of BRAF/MEK/14-3-3 complexes"
15:45 Break
16:00 Luke O'Neill "Adventures in inflammation research"
16:45 Gioacchino Natoli "Keeping transcription focused: a novel checkpoint that selectively limits extragenic transcription"
17:30 Break
17:40 Poster Session
Program - February 12
The time indicated in the schedule is intended as Central European Time
SESSION 1 : STEM CELLS
9:00 Austin Smith "Pluripotency: one cell for all"
9:45 Jonathan Chubb "Single cell decision making during development and dedifferentiation"
10:30 Paulina Latos "Repressive mechanisms governing trophoblast identity"
11:15 Break
11:30 Maria Carolina Florian "Aging of hematopoietic stem cells: epigenetic drift and remodeling of the niche"
12:15 Sara Wickström "Nuclear mechanotransduction: regulation of cell fate and integrity"
13:00 Break
SESSION 2: NUCLEAR ORGANIZATION
14:00 Susana Gonzalo "Danger of self-DNA accumulation in the cytoplasm during aging"
14:45 Ulrike Kutay "Inside Out – Taking Apart the Nuclear Envelope for Open Mitosis"
15:30 Colin Stewart "LINC complex disruption as a way to treat laminopathies"
16:15 Break
16:30 Fabrizio d'Adda di Fagagna "DNA damage response: threat and opportunities"
17:15 Wendy Bickmore "Enhancer function and the 3D genome"
18:00 Tom Misteli "Genome organization in space and time"
18:45 Concluding Remarks